Cynomolgus Monkey (Macaca fascicularis) CXCL11 (C-X-C motif chemokine ligand 11), also known as I-TAC (Interferon-inducible T-cell alpha chemoattractant), is a proinflammatory chemokine belonging to the CXC chemokine family, which also includes CXCL9 (MIG) and CXCL10 (IP-10) that regulate T-cell recruitment during antiviral and inflammatory immune responses. In cynomolgus monkeys, CXCL11 is produced by macrophages, dendritic cells, epithelial cells, endothelial cells, and fibroblasts in response to interferon-γ (IFN-γ), viral infection, or inflammatory cytokines. CXCL11 signals primarily through the chemokine receptor CXCR3, which is expressed on activated T lymphocytes, natural killer (NK) cells, and other immune cells, promoting chemotaxis and activation of these cells at sites of infection or inflammation. Because cynomolgus monkeys share strong genetic and immunological similarity with humans, they are widely used as preclinical animal models for infectious diseases, immunology, and vaccine development, including studies of SARS-CoV-2, dengue virus, and other viral pathogens. In these models, CXCL11 is part of the interferon-driven chemokine network that recruits CXCR3⁺ T cells to infected tissues, making cynomolgus monkey CXCL11 an important marker for studying antiviral immune responses, inflammatory signaling, and evaluation of antiviral therapies and vaccines.