Bovine CXCL6 (C-X-C motif chemokine ligand 6), also known as GCP-2 (granulocyte chemotactic protein 2), is a proinflammatory chemokine belonging to the ELR⁺ CXC chemokine family, which includes CXCL1, CXCL2, CXCL3, and CXCL5 that regulate neutrophil recruitment during inflammatory responses. In cattle (Bos taurus), CXCL6 is produced by macrophages, epithelial cells, endothelial cells, and fibroblasts in response to proinflammatory cytokines such as IL-1β and TNF-α, bacterial infection, or tissue injury. CXCL6 primarily signals through the chemokine receptor CXCR2, expressed on neutrophils and other innate immune cells, promoting chemotaxis, activation, and migration of neutrophils to sites of infection or inflammation. In bovine health, CXCL6 contributes to innate immune defense against bacterial pathogens, particularly in tissues such as the mammary gland and respiratory tract, where rapid neutrophil recruitment is critical for controlling infections associated with mastitis and bovine respiratory disease complex. Because neutrophil-driven inflammatory responses are central to host defense in cattle, bovine CXCL6 is studied in veterinary immunology, mastitis research, and host–pathogen interaction studies to better understand chemokine-mediated neutrophil trafficking and inflammatory signaling in livestock disease.