Human CCL24 (C-C motif chemokine ligand 24, also known as eotaxin-2 or MPIF-2, macrophage inflammatory protein-4) is a chemokine that plays an important role in recruitment of eosinophils and regulation of type 2 immune responses. CCL24 primarily signals through the CCR3 receptor, promoting chemotaxis of eosinophils, basophils, and Th2 lymphocytes to sites of infection, allergic inflammation, or tissue injury. In humans, CCL24 is produced by epithelial cells, macrophages, endothelial cells, and fibroblasts in response to Th2-associated cytokines such as IL-4 and IL-13. It is particularly active in mucosal and barrier tissues, including the lungs, gastrointestinal tract, and skin, where it contributes to immune defense against parasites but is also involved in allergic inflammation. Dysregulated or elevated CCL24 expression has been implicated in asthma, allergic rhinitis, atopic dermatitis, eosinophilic esophagitis, and other eosinophil-associated inflammatory diseases, where excessive eosinophil recruitment contributes to tissue inflammation and damage. CCL24 also participates in fibrotic disease processes, including pulmonary and liver fibrosis, through recruitment of inflammatory cells and modulation of tissue remodeling pathways. Because of its central role in eosinophil trafficking and Th2-mediated inflammation, human CCL24 is studied as both a biomarker and potential therapeutic target in allergic disease, chronic inflammation, and fibrotic disorders.