Mouse CCL24 Recombinant Protein

Catalog Number:
RP2278M
Availability:
In stock
Application:
Cell Culture, Control, ELISA, ELISpot Control, Western Blot Control
100% Homology:
Mus musculus (house mouse)
  • Mouse CCL24 (C-C Motif Chemokine Ligand 24) (catalog RP2278M) is a yeast-derived cytokine supplied lyophilized without carrier protein in 10% trehalose; it contains no affinity tags, is naturally endotoxin-free, and should be reconstituted in sterile PBS with at least 0.1% carrier protein. The protein is ~10.3 kDa, 93 amino acids in length (full sequence provided), and >98% pure by SDS-PAGE, with 100% amino-acid homology to house mouse. It is stable for up to twelve months at -20 °C from receipt, with working aliquots (with carrier protein) stable for ~3 months; avoid repeated freeze/thaw cycles. The product is manufactured in the USA. It is commonly used to study chemokine-mediated immune responses, particularly eosinophil recruitment, allergic inflammation, and cytokine signaling pathways; typical applications include chemotaxis and cell migration assays, immune cell activation studies, cytokine signaling research, ELISA and neutralization assays, flow cytometry and Western blot controls, and antibody development or validation. Kingfisher Biotech products are supplied for research applications only and are not intended for medicinal, diagnostic, or therapeutic use.
Amino Acid SequenceVTIPSSCCTS FISKKIPENR VVSYQLANGS ICPKAGVIFI TKKGHKICTD PKLLWVQRHI QKLDAKKNQP SKGAKAVRTK FAVQRRRGNS TEV (93)
EndotoxinNaturally endotoxin-free
FormLyophilized
Storage Conditions-20°C
Molecular Weight10.3 kDa
Purity>98% as visualized by SDS-PAGE analysis.
Expression SystemYeast
FormLyophilized
Country Of OriginUSA
Mouse CCL24 (C-C motif chemokine ligand 24, also known as eotaxin-2 or MPIF-2, macrophage inflammatory protein-4) is a chemokine that regulates recruitment of eosinophils and other immune cells involved in type 2 inflammatory responses in mice (Mus musculus). CCL24 primarily signals through the CCR3 receptor, promoting chemotaxis of eosinophils, basophils, and Th2 lymphocytes to sites of infection, allergic inflammation, or tissue injury. In mice, CCL24 is produced by epithelial cells, macrophages, fibroblasts, and endothelial cells in response to type 2 cytokines such as IL-4 and IL-13, which drive Th2-associated immune responses. Mouse CCL24 plays an important role in experimental models of allergic airway disease (asthma), parasitic helminth infections, and eosinophil-driven inflammation, where it contributes to recruitment of eosinophils into lung and mucosal tissues. While CCL24-mediated eosinophil trafficking supports protective immunity against parasites and participates in tissue repair, excessive or prolonged expression can promote chronic allergic inflammation and tissue remodeling. Because mice are widely used as genetic models for studying allergic disease, parasite immunity, and Th2-mediated inflammation, characterization of mouse CCL24 has been important for understanding CCR3-dependent eosinophil recruitment and developing therapeutic strategies targeting eosinophilic inflammatory disorders.

Please choose a size to see price


Reagents for Animal Model and Animal Health Research

Kingfisher Biotech, Inc.
1000 Westgate Drive
Suite 123
Saint Paul, MN 55114

Phone: 651-646-0089
Fax: 651-646-0095

Animal Antibodies

Newsletter

"