Rabbit EGF (Epidermal Growth Factor) is a growth factor peptide belonging to the EGF family of ligands, which also includes transforming growth factor-α (TGF-α), amphiregulin (AREG), heparin-binding EGF-like growth factor (HB-EGF), betacellulin (BTC), and epiregulin (EREG) that signal through the epidermal growth factor receptor (EGFR/ErbB1) to regulate cell proliferation, differentiation, and tissue repair. In rabbits (Oryctolagus cuniculus), EGF is produced by epithelial cells, fibroblasts, macrophages, and glandular tissues such as salivary glands and gastrointestinal epithelium, where it supports epithelial maintenance, mucosal integrity, and wound healing. Binding of EGF to EGFR activates intracellular signaling pathways including MAPK/ERK, PI3K–AKT, and JAK/STAT, which promote cell proliferation, survival, and tissue regeneration following injury or inflammation. In rabbit physiology, EGF plays a key role in repair of skin and gastrointestinal epithelial tissues, helping restore barrier function after damage. Rabbits are also widely used as animal models for wound healing and ophthalmic research, and EGF signaling has been studied in rabbit models of corneal injury, where EGFR-mediated pathways regulate corneal epithelial regeneration and tissue repair, providing insights relevant to both veterinary medicine and human ocular therapeutics.