Jamaican Fruit-eating Bat EGF (Epidermal Growth Factor) is a growth factor peptide belonging to the EGF family of ligands, which also includes transforming growth factor-α (TGF-α), amphiregulin (AREG), heparin-binding EGF-like growth factor (HB-EGF), betacellulin (BTC), and epiregulin (EREG) that signal through the epidermal growth factor receptor (EGFR/ErbB1) to regulate cell proliferation, differentiation, and tissue repair. In the Jamaican fruit-eating bat (Artibeus jamaicensis), EGF is likely produced by epithelial cells, fibroblasts, macrophages, and various glandular tissues, where it functions in epithelial maintenance, wound healing, and regulation of tissue growth. EGF binds to EGFR, activating downstream signaling pathways such as MAPK/ERK, PI3K-AKT, and JAK/STAT, which promote cell survival, proliferation, and regeneration of epithelial tissues. In bats, growth factors such as EGF may contribute to the efficient tissue repair and regenerative capacity observed in bat species, particularly in tissues exposed to environmental stress or injury. Because bats serve as important reservoirs for several zoonotic viruses, including coronaviruses and other emerging pathogens, studying signaling molecules like EGF helps researchers understand cellular repair mechanisms and host–pathogen interactions in bat biology. These insights contribute to comparative immunology and regenerative biology research, providing clues to how bats maintain tissue integrity while tolerating viral infections.