Jamaican Fruit-eating Bat (Artibeus jamaicensis) CCL2 (C-C motif chemokine ligand 2), also known as monocyte chemoattractant protein-1 (MCP-1), is a pro-inflammatory chemokine that plays an important role in recruitment of monocytes, macrophages, and other immune cells to sites of infection or tissue injury. CCL2 signals primarily through the CCR2 receptor, activating downstream pathways that promote leukocyte migration, inflammatory cytokine production, and coordination of innate immune responses. In A. jamaicensis, a bat species that serves as a reservoir for diverse viral pathogens, CCL2 is of particular interest for understanding how immune cell recruitment is regulated during infection while limiting excessive inflammatory damage. Controlled expression of CCL2 may contribute to balanced inflammatory responses and tissue repair, supporting the ability of bats to tolerate viral infections with minimal clinical disease. Characterization of Jamaican Fruit-eating Bat CCL2 provides insight into chemokine-mediated immune regulation, host–pathogen interactions, and mechanisms of viral tolerance in reservoir species. Studying CCL2 signaling in this context enhances comparative immunology research and may inform strategies to better understand inflammatory regulation and immune-mediated pathology in humans.