Jamaican Fruit-eating Bat (Artibeus jamaicensis) CXCL11 (C-X-C motif chemokine ligand 11), also known as I-TAC (Interferon-inducible T-cell alpha chemoattractant), is a proinflammatory chemokine belonging to the CXC chemokine family, which also includes CXCL9 (MIG) and CXCL10 (IP-10) that regulate T-cell recruitment during antiviral immune responses. In Jamaican fruit-eating bats, CXCL11 is produced by macrophages, dendritic cells, endothelial cells, epithelial cells, and other tissue cells in response to interferon signaling, viral infection, or inflammatory cytokines. CXCL11 signals through the chemokine receptor CXCR3, expressed on activated T lymphocytes, natural killer (NK) cells, and other immune cells, promoting chemotaxis and activation of these cells at sites of infection or inflammation. As bats serve as reservoirs for numerous viruses, including coronaviruses and other emerging zoonotic pathogens, CXCL11 likely contributes to interferon-driven antiviral immunity and recruitment of cytotoxic immune cells during infection. Characterizing CXCL11 in Jamaican fruit-eating bats supports research into bat immune system adaptations and host–pathogen interactions, helping to explain how bats can control viral replication while limiting excessive inflammatory responses, an area of interest for zoonotic disease and comparative immunology research.