Swine CXCL2 (C-X-C motif chemokine ligand 2), also known as MIP-2α (macrophage inflammatory protein-2 alpha) or GRO-β (growth-regulated oncogene beta), is a proinflammatory chemokine belonging to the ELR⁺ CXC chemokine family, which includes CXCL1, CXCL3, CXCL5, CXCL6, and CXCL7 that regulate neutrophil recruitment and activation during inflammatory responses. In pigs (Sus scrofa), CXCL2 is produced by macrophages, monocytes, epithelial cells, endothelial cells, and fibroblasts in response to proinflammatory cytokines such as IL-1β and TNF-α, microbial infection, or tissue injury. CXCL2 primarily signals through the chemokine receptor CXCR2, expressed on neutrophils and other innate immune cells, promoting chemotaxis, activation, and migration of neutrophils to sites of infection or inflammation. In swine health, CXCL2 plays an important role in innate immune defense against respiratory and enteric pathogens, particularly during infections caused by swine influenza virus (IAV-S), porcine reproductive and respiratory syndrome virus (PRRSV), and secondary bacterial pathogens. Because pigs share important anatomical, physiological, and immunological similarities with humans, they are widely used as translational animal models for respiratory disease and inflammatory research. CXCL2-mediated neutrophil responses have been studied in porcine models of influenza infection, where elevated CXCL2 expression in the lungs contributes to recruitment of neutrophils to infected airways, antiviral host defense, and regulation of pulmonary inflammation, providing insights relevant to both swine health and human respiratory disease research