Bovine CCL11 (C-C motif chemokine ligand 11), also known as eotaxin-1, is a member of the CC chemokine family that regulates eosinophil recruitment and type 2–associated immune responses in cattle (Bos taurus). CCL11 is produced primarily by epithelial cells, fibroblasts, endothelial cells, and activated immune cells in response to Th2-associated cytokines such as IL-4 and IL-13, and it functions mainly through the CCR3 receptor to promote chemotaxis and activation of eosinophils, as well as certain Th2 lymphocytes and basophils. In healthy cattle, basal CCL11 expression is typically low, but levels may increase during parasitic infections—particularly gastrointestinal nematode and lungworm infections—as well as allergic-type inflammation, mastitis-associated immune responses, and respiratory disease. In veterinary and agricultural research, bovine CCL11 serves as a biomarker of Th2-skewed immunity and eosinophilic inflammation, providing insight into host defense against helminths, vaccine responses, and immune regulation in cattle.