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Canine IL-1 beta Biotinylated Recombinant Protein
- Catalog Number:
- RPB1839D
- Availability:
- In stock
- Application:
- Cell Culture
- 100% Homology:
- Canis lupus dingo (dingo), Canis lupus familiaris (dog)
- Label:
- Biotin
- The Canine IL-1 beta Biotinylated yeast-derived recombinant protein is not tagged and is naturally endotoxin-free. The purity is greater than 98% as visualized by SDS-PAGE analysis. Canine IL-1 beta Biotinylated applications are for cell culture. Canine IL-1 beta Biotinylated yeast-derived recombinant protein can be purchased in multiple sizes. Canine IL-1 beta Biotinylated Specifications: (Molecular Weight: 17.5 kDa) (Amino Acid Sequence: AAMQSVDCKLQDISHKYLVLSNSYELRALHLNGENVNKQVVFHMSFVHGDESNNKIPVVLGIKQKNLYLSCVMKDGKPTLQLEKVDPKVYPKRKMEKRFVFNKIEIKNTVEFESSQYPNWYISTSQVEGMPVFLGNTRGGQDITDFTMEFSS) (Gene ID: 403974). For research use only.
| Amino Acid Sequence | AAMQSVDCKL QDISHKYLVL SNSYELRALH LNGENVNKQV VFHMSFVHGD ESNNKIPVVL GIKQKNLYLS CVMKDGKPTL QLEKVDPKVY PKRKMEKRFV FNKIEIKNTV EFESSQYPNW YISTSQVEGM PVFLGNTRGG QDITDFTMEF SS (152) |
| Endotoxin | Naturally endotoxin-free |
| Storage Conditions | -20°C |
| Purity | >98% as visualized by SDS-PAGE analysis. |
| Country Of Origin | USA |
- Canine Interleukin-1 Beta (IL-1β) is a potent pro-inflammatory cytokine produced primarily by activated macrophages, monocytes, and dendritic cells in dogs (Canis lupus familiaris) following recognition of pathogens or tissue damage. Synthesized as an inactive precursor (pro-IL-1β), it is cleaved into its active form by caspase-1 within the inflammasome complex and subsequently binds to the IL-1 receptor (IL-1R1), activating NF-κB and MAPK signaling pathways that drive fever, leukocyte recruitment, endothelial activation, and acute-phase protein production. In canine health, IL-1β plays a central role in inflammatory and infectious conditions including bacterial pneumonia, pyometra, parvoviral enteritis, osteoarthritis, immune-mediated diseases, and sepsis, where excessive or sustained IL-1β production can contribute to tissue damage and systemic inflammation. Elevated IL-1β levels are also associated with chronic inflammatory disorders and certain cancers, reflecting its role in shaping the tumor microenvironment. As both a biomarker and therapeutic target, canine IL-1β is important in veterinary medicine for monitoring inflammatory status and evaluating anti-inflammatory interventions. In translational research, dogs serve as valuable spontaneous models for human osteoarthritis, inflammatory bowel disease, sepsis, and cancer, and characterization of canine IL-1β supports studies of inflammasome activation, cytokine-driven pathology, and development of targeted immunomodulatory therapies relevant to both canine and human health.
10 ug
Price: $200.00