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Canine IL-2 Biotinylated Recombinant Protein
- Catalog Number:
- RPB1852D
- Availability:
- In stock
- Application:
- Cell Culture
- 100% Homology:
- Canis lupus dingo (dingo), Canis lupus familiaris (dog), Nyctereutes procyonoides (raccoon dog), Vulpes lagopus (Arctic fox), Vulpes vulpes (red fox)
- Label:
- Biotin
- The Canine IL-2 Biotinylated yeast-derived recombinant protein is not tagged and is naturally endotoxin-free. The purity is greater than 98% as visualized by SDS-PAGE analysis. Canine IL-2 Biotinylated applications are for cell culture. Canine IL-2 Biotinylated yeast-derived recombinant protein can be purchased in multiple sizes. Canine IL-2 Biotinylated Specifications: (Molecular Weight: 15.5 kDa) (Amino Acid Sequence: APITSSSTKETEQQMEQLLLDLQLLLNGVNNYENPQLSRMLTFKFYTPKKATEFTHLQCLAEELKNLEEVLGLPQSKNVHLTDTKELISNMNVTLLKLKGSETSYNCEYDDETATITEFLNKWITFCQSIFSTLT (135)) (Gene ID: 403989). For research use only.
| Amino Acid Sequence | APITSSSTKE TEQQMEQLLL DLQLLLNGVN NYENPQLSRM LTFKFYTPKK ATEFTHLQCL AEELKNLEEV LGLPQSKNVH LTDTKELISN MNVTLLKLKG SETSYNCEYD DETATITEFL NKWITFCQSI FSTLT (135) |
| Endotoxin | Naturally endotoxin-free |
| Storage Conditions | -20°C |
| Purity | >98% as visualized by SDS-PAGE analysis. |
| Country Of Origin | USA |
- Canine IL-2 (Interleukin-2) is a central T cell-derived cytokine that regulates lymphocyte proliferation, differentiation, and immune homeostasis in dogs (Canis lupus familiaris). IL-2 is produced primarily by activated CD4⁺ and CD8⁺ T lymphocytes following antigen recognition and costimulatory signaling, and it functions through the IL-2 receptor complex (IL-2Rα/CD25, IL-2Rβ, and the common γ chain) to promote clonal expansion of antigen-specific T cells, enhance cytotoxic T lymphocyte and natural killer (NK) cell activity, and support development and maintenance of regulatory T cells (Tregs). In healthy dogs, basal IL-2 expression is typically low but increases during infection, vaccination, and immune stimulation. Altered IL-2 responses have been associated with canine distemper virus, leishmaniasis, chronic inflammatory diseases, and immune-mediated disorders. Dogs serve as important translational animal models for human lymphoma and other cancers, atopic dermatitis, autoimmune disease, and certain neuroinflammatory and infectious diseases. In veterinary and comparative medicine research, canine IL-2 is widely used as a biomarker of T cell activation and cell-mediated immunity and has been investigated as an immunotherapeutic agent in oncology and chronic infectious disease settings.
10 ug
Price: $200.00