Swine IL-22 Biotinylated Recombinant Protein

The Swine IL-22 Biotinylated yeast-derived recombinant protein is not tagged and is naturally endotoxin-free. The purity is greater than 98% as visualized by SDS-PAGE analysis. Swine IL-22 Biotinylated applications are for cell culture. Swine IL-22 Biotinylated yeast-derived recombinant protein can be purchased in multiple sizes. Swine IL-22 Biotinylated Specifications: (Molecular Weight: 18.0 kDa) (Amino Acid Sequence: VPITHHCKLD QSNFQQPYIT NRTFTLAQEA SLADNNTDVR LIGNNLFQGV NMRERCYLVK QVLNFTLEEV LFPNSDRFHP YMQEVASFLD SLSKKLSQCR IKGDDQHIQR NVNNFKDTVK KLGESGEIKV IGELYLLFMA LKNECTLPGH SWKMDN (156)) (Gene ID: 595104). For research use only.

Amino Acid Sequence	VPITHHCKLD QSNFQQPYIT NRTFTLAQEA SLADNNTDVR LIGNNLFQGV NMRERCYLVK QVLNFTLEEV LFPNSDRFHP YMQEVASFLD SLSKKLSQCR IKGDDQHIQR NVNNFKDTVK KLGESGEIKV IGELYLLFMA LKNECTLPGH SWKMDN (156)
Endotoxin	Naturally endotoxin-free

Storage Conditions	-20°C
Purity	>98% as visualized by SDS-PAGE analysis.
Country Of Origin	USA

Swine IL-22 (Interleukin-22) is a member of the IL-10 cytokine family that plays a key role in mucosal immunity and epithelial barrier protection in pigs (Sus scrofa). IL-22 is produced primarily by activated CD4⁺ T cells, including Th17- and Th22-like subsets, as well as by γδ T cells and innate lymphoid cells (ILC3s), in response to microbial infection and inflammatory stimulation. It signals through the IL-22 receptor complex (IL-22R1 and IL-10R2), expressed mainly on epithelial and stromal cells, activating downstream JAK/STAT pathways-particularly STAT3-to induce antimicrobial peptide production, enhance chemokine expression, promote epithelial cell proliferation, and support tissue repair. In healthy swine, basal IL-22 expression is generally low but increases during bacterial, viral, and parasitic infections, particularly at mucosal surfaces of the gastrointestinal and respiratory tracts. Swine IL-22 has been implicated in immune responses to enteric pathogens such as Escherichia coli and Salmonella, as well as respiratory pathogens including porcine reproductive and respiratory syndrome virus (PRRSV) and swine influenza virus. In veterinary and translational research, swine IL-22 serves as a biomarker of mucosal immune activation and epithelial defense and is studied in the context of host-pathogen interactions, vaccine efficacy, and maintenance of barrier integrity in both agricultural and biomedical disease models.

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Price: $200.00