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Guinea Pig TNF alpha Biotinylated Recombinant Protein
- Catalog Number:
- RPB1884GP
- Availability:
- In stock
- Application:
- Cell Culture
- 100% Homology:
- Cavia porcellus (domestic guinea pig)
- Label:
- Biotin
- The Guinea Pig TNF alpha Biotinylated yeast-derived recombinant protein is not tagged and is naturally endotoxin-free. The purity is greater than 98% as visualized by SDS-PAGE analysis. Guinea Pig TNF alpha Biotinylated applications are for cell culture. Guinea Pig TNF alpha Biotinylated yeast-derived recombinant protein can be purchased in multiple sizes. Guinea Pig TNF alpha Biotinylated Specifications: (Molecular Weight: 17.0 kDa) (Amino Acid Sequence: SASQNDNDKP VAHVVANQQA EEELQWLSKR ANALLANGMG LSDNQLVVPS DGLYLIYSQV LFKGQGCPSY LLLTHTVSRL AVSYPEKVNL LSAIKSPCQK ETPEGAERKP WYEPIYLGGV FQLQKGDRLS AEVNLPQYLD FADSGQIYFG VIAL (154)) (Gene ID: 100135630). For research use only.
| Amino Acid Sequence | SASQNDNDKP VAHVVANQQA EEELQWLSKR ANALLANGMG LSDNQLVVPS DGLYLIYSQV LFKGQGCPSY LLLTHTVSRL AVSYPEKVNL LSAIKSPCQK ETPEGAERKP WYEPIYLGGV FQLQKGDRLS AEVNLPQYLD FADSGQIYFG VIAL (154) |
| Endotoxin | Naturally endotoxin-free |
| Storage Conditions | -20°C |
| Purity | >98% as visualized by SDS-PAGE analysis. |
| Country Of Origin | USA |
- Guinea Pig Tumor Necrosis Factor Alpha (TNF-α) (also known as TNF or cachectin) is a proinflammatory cytokine that plays a central role in innate immune responses, inflammation, and host defense against pathogens in guinea pigs (Cavia porcellus). TNF-α is a member of the tumor necrosis factor (TNF) superfamily, which includes related cytokines such as TNF-β (lymphotoxin-α), Fas ligand (FasL), CD40 ligand (CD40L), and TRAIL, proteins that regulate immune signaling, apoptosis, and inflammatory pathways. In guinea pigs, TNF-α is primarily produced by activated macrophages, monocytes, dendritic cells, and T lymphocytes in response to infection, endotoxin exposure, or tissue injury. TNF-α exerts its biological effects by binding to TNF receptors TNFR1 (p55) and TNFR2 (p75), activating intracellular signaling pathways including NF-κB, MAPK, and caspase-mediated pathways, which regulate cytokine production, immune cell activation, apoptosis, and inflammatory responses. In guinea pigs, TNF-α is particularly important in immune responses to intracellular bacterial infections such as Mycobacterium tuberculosis, for which guinea pigs serve as a well-established animal model of human tuberculosis due to their similar disease pathology and granuloma formation. TNF-α contributes to macrophage activation, granuloma maintenance, and containment of mycobacterial infection, although excessive TNF signaling can also contribute to tissue inflammation and pathology. Because guinea pigs are widely used in infectious disease, immunology, and tuberculosis research, characterization of guinea pig TNF-α supports studies of cytokine regulation, host-pathogen interactions, and inflammatory responses relevant to both veterinary and human health.
10 ug
Price: $200.00