Bovine CXCL11 (C-X-C motif chemokine ligand 11), also known as I-TAC (Interferon-inducible T-cell alpha chemoattractant), is a proinflammatory chemokine belonging to the CXC chemokine family, which also includes CXCL9 (MIG) and CXCL10 (IP-10) that regulate T-cell recruitment during antiviral and inflammatory immune responses. In cattle (Bos taurus), CXCL11 is produced by macrophages, dendritic cells, endothelial cells, epithelial cells, and fibroblasts in response to interferon-γ (IFN-γ), microbial infection, or inflammatory cytokines. CXCL11 signals through the chemokine receptor CXCR3, which is expressed on activated T lymphocytes, natural killer (NK) cells, and other immune cells, promoting chemotaxis and activation of these cells at sites of infection or inflammation. In bovine health, CXCL11 contributes to Th1-type immune responses against intracellular pathogens, including Mycobacterium bovis, the causative agent of bovine tuberculosis, where CXCL11-mediated recruitment of CXCR3⁺ T cells supports granuloma formation and cellular immune defense. Because bovine tuberculosis shares important immunopathological features with human tuberculosis, cattle are used as comparative animal models for tuberculosis research, and bovine CXCL11 is studied as part of the interferon-driven chemokine network involved in T-cell trafficking, host–pathogen interactions, and development of diagnostic and vaccine strategies.