Ferret CCL8 (C–C motif chemokine ligand 8, also known as MCP-2 – Monocyte Chemoattractant Protein-2) is a proinflammatory chemokine involved in leukocyte recruitment and regulation of inflammatory responses in ferrets (Mustela putorius furo). CCL8 is a member of the CC chemokine family, which includes related chemokines such as CCL2 (MCP-1), CCL7 (MCP-3), and CCL13 (MCP-4) that coordinate monocyte and leukocyte trafficking during immune activation. In ferrets, CCL8 is produced by macrophages, fibroblasts, endothelial cells, epithelial cells, and other immune cells in response to infection, inflammatory cytokines, or tissue injury. CCL8 exerts its biological effects through interaction with chemokine receptors including CCR1, CCR2, CCR3, and CCR5, promoting chemotaxis and activation of monocytes, macrophages, dendritic cells, T lymphocytes, and eosinophils at sites of infection or inflammation. Ferrets are widely used as animal models for respiratory viral infections, particularly influenza and coronaviruses, and chemokines such as CCL8 are important for recruiting immune cells to the respiratory tract and regulating inflammatory responses during viral infection. Consequently, ferret CCL8 is studied in infectious disease, immunology, and vaccine research, helping to elucidate mechanisms of chemokine-mediated immune cell trafficking and host responses to respiratory pathogens.