Swine CCL2 (C-C motif chemokine ligand 2, also known as monocyte chemoattractant protein-1, MCP-1) is a pro-inflammatory chemokine that plays an important role in recruitment and activation of monocytes, macrophages, and memory T cells during immune responses in pigs (Sus scrofa domesticus). CCL2 signals primarily through the CCR2 receptor, activating intracellular pathways that promote leukocyte migration, cytokine production, and coordination of innate and adaptive immune responses at sites of infection, inflammation, or tissue injury. In swine health, CCL2 is particularly relevant in respiratory and systemic infectious diseases, including porcine reproductive and respiratory syndrome virus (PRRSV), swine influenza, and bacterial pneumonia, where monocyte and macrophage recruitment to the lungs influences both antiviral defense and inflammatory lung pathology. CCL2 is also involved in inflammatory responses in tissues such as the gut and joints, contributing to immune cell infiltration and tissue remodeling. While CCL2-mediated immune cell trafficking supports pathogen clearance and tissue repair, excessive or prolonged expression can contribute to chronic inflammation and tissue damage. Because pigs are widely used as large-animal models for human infectious, inflammatory, and cardiovascular diseases, characterization of swine CCL2 supports research into chemokine-mediated immune regulation, host–pathogen interactions, and development of anti-inflammatory or immunomodulatory therapies relevant to both veterinary and human medicine.