Swine Vascular Endothelial Growth Factor A (VEGF-A) is a member of the vascular endothelial growth factor (VEGF) family, which includes VEGF-A, VEGF-B, VEGF-C, VEGF-D, and placental growth factor (PlGF)—key regulators of angiogenesis, vascular permeability, and endothelial cell growth. In pigs (Sus scrofa), VEGF-A is produced by multiple cell types including endothelial cells, macrophages, fibroblasts, epithelial cells, smooth muscle cells, and tumor cells, particularly in response to hypoxia, inflammation, and tissue injury. VEGF-A exerts its biological effects primarily through binding to VEGF receptor-1 (VEGFR-1/Flt-1) and VEGF receptor-2 (VEGFR-2/KDR) on endothelial cells, activating intracellular signaling pathways such as MAPK/ERK, PI3K/AKT, and PLCγ, which promote endothelial cell proliferation, migration, vascular permeability, and formation of new blood vessels. In swine physiology, VEGF-A plays important roles in vascular development, tissue regeneration, reproductive physiology, and placental angiogenesis, supporting maternal–fetal blood supply during pregnancy. VEGF-A is also involved in muscle vascularization and tissue repair following injury or ischemia. Because pigs share many physiological similarities with humans, swine VEGF-A is widely studied in large-animal models of cardiovascular disease, ischemia, wound healing, and regenerative medicine, contributing to translational research on angiogenesis and therapeutic strategies targeting VEGF signaling.