Egyptian Rousette Bat IL-17A ELISA

Catalog Number:
DIY2271BT
Availability:
In stock
Application:
ELISA
100% Homology:
Rousettus aegyptiacus (Egyptian rousette)

Components

UsageQuantityComponentSize
Detection Antibody50 µgKPB2270BT-050
Standard5 µgRP2121BT-005
Capture Antibody100 µgKP2269BT-1001 Pack (<= 10 Plates)
Capture Antibody100 µg X 2KP2269BT-1001 Pack (<= 20 Plates)
  • The Egyptian Rousette Bat IL-17A (Interleukin-17A) ELISA is designed for the quantitative measurement of IL-17A in cell culture supernatants from Egyptian rousette bats (Rousettus aegyptiacus) and can also be used to measure IL-17A in additional biological sample types reported in the literature, including serum, plasma, bronchoalveolar lavage (BAL) fluid, and tissue lysates, with minor protocol modifications recommended to optimize performance across different matrices. IL-17A is a pro-inflammatory cytokine primarily produced by Th17 cells, γδ T cells, and other innate lymphoid populations, where it plays a central role in host defense against extracellular bacteria and fungi by stimulating epithelial and stromal cells to produce chemokines and antimicrobial peptides, thereby promoting neutrophil recruitment and mucosal immune protection. In healthy Egyptian rousette bats, circulating IL-17A levels are typically low or near the limit of detection, but concentrations may increase during viral or bacterial infection, inflammatory stimulation, or experimental immune challenge, depending on pathogen exposure and timing of sampling. In bat immunology and emerging infectious disease research, IL-17A serves as an important biomarker of Th17-type immune activation, mucosal inflammatory responses, and host-pathogen interactions, particularly in studies of zoonotic viruses for which Egyptian rousette bats are recognized natural reservoir hosts, including Marburg virus and related filoviruses. The ELISA kit contains a capture antibody, detection antibody, and recombinant Egyptian rousette bat IL-17A protein standard validated for use together in an ELISA format; kit components are not supplied in matched quantities and may be purchased separately. This product is for research use only, not for use in diagnostic or therapeutic procedures, and is manufactured in the USA.
Storage Conditions2°C to 8°C or -20°C
Country Of OriginUSA
Egyptian rousette bat IL-17A (Interleukin-17A) is a pro-inflammatory cytokine belonging to the IL-17 family that plays a key role in regulating host defense and inflammatory responses in the Egyptian rousette bat (Rousettus aegyptiacus). IL-17A is produced primarily by Th17 cells and other IL-17–producing lymphocytes, including γδ T cells and innate lymphoid cells, in response to infection or immune stimulation. It acts on epithelial, endothelial, and stromal cells to induce expression of pro-inflammatory cytokines, chemokines, and antimicrobial peptides, thereby promoting neutrophil recruitment and enhancing mucosal immunity. In healthy bats, basal IL-17A expression is expected to be low, but levels may increase during bacterial or fungal infection, tissue injury, or experimental immune activation. Given that Egyptian rousette bats are natural reservoir hosts for pathogens such as Marburg virus and other zoonotic viruses, characterization of IL-17A responses in this species is of particular interest for understanding how bats balance effective pathogen control with limited immunopathology. Study of Egyptian rousette bat IL-17A provides valuable insight into Th17-mediated immunity, mucosal defense mechanisms, and the unique immune regulatory strategies that enable bats to tolerate viral infections.

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